منابع مشابه
Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase.
Hexokinase type II is highly overexpressed in many cancer cells, where it plays a pivotal role in the high glycolytic phenotype. Here we demonstrate by Southern blot analysis and fluorescence in situ hybridization (FISH) that in the rapidly growing rat AS-30D hepatoma cell line, enhanced hexokinase activity is associated with at least a 5-fold amplification of the type II gene relative to norma...
متن کاملEncoding Type II Hexokinase Glucose Catabolism in Cancer Cells: Amplification of the Gene
Hexokinase type II is highly overexpressed in many cancer cells, where it plays a pivotal role in the high glycolytic phenotype. Here we demon strate by Southern blot analysis and fluorescence in situ hybridization (FISH) that in the rapidly growing rat AS-30D hepatoma cell line, en hanced hexokinase activity is associated with at least a 5-fold amplification of the type II gene relativeto norm...
متن کاملGlucose Catabolism in Cancer Cells: Amplification of the Gene Encoding Type II Hexokinase1
Hexokinase type II is highly overexpressed in many cancer cells, where it plays a pivotal role in the high glycolytic phenotype. Here we demon strate by Southern blot analysis and fluorescence in situ hybridization (FISH) that in the rapidly growing rat AS-30D hepatoma cell line, en hanced hexokinase activity is associated with at least a 5-fold amplification of the type II gene relativeto norm...
متن کاملGlucose catabolism in fetal and adult heart.
The cells of growing and developing organisms are generally characterized by a higher rate of protein synthesis than is found in the cells of mature forms, and it has been shown repeatedly (1) that increases in rate of protein synthesis are associated with higher RNA content. It might then be expected that enaymes necessary for ribose synthesis would be in greater supply in rapidly proliferatin...
متن کاملPathways of Glucose Catabolism in Bacillus Subtilis.
Goldman, Manuel (The University of Michigan, Ann Arbor) and Harold J. Blumenthal. Pathways of glucose catabolism in Bacillus subtilis. J. Bacteriol. 86:303-311. 1963.-Under aerobic conditions, resting cells of Bacillus subtilis Marburg C4 catabolized 60 to 70% of glucose by the Embden-Meyerhof pathway and the remainder by the hexose monophosphate pathway; under anaerobic conditions, the percent...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.36.22776